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Paper Summary of RainMed's caFFR & caIMR (2)

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(Summary description)Paper Summary of RainMed's caFFR and caIMR (2)

Paper Summary of RainMed's caFFR & caIMR (2)

(Summary description)Paper Summary of RainMed's caFFR and caIMR (2)

  • Categories:News Center
  • Author:
  • Origin:
  • Time of issue:2023-04-28 15:14
  • Views:
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At present, RainMed Medical’s product pipeline has entered the fast track of development. The company has fully implemented the strategic planning of FlashBot vascular interventional surgical robot, expanded the domestic and overseas marketing network of its commercialized product caFFR system, and promoted the large-scale clinical study of its commercialized product caIMR system. Looking back to 2022, domestic and foreign clinical researchers of RainMed continue to explore the field of coronary precision diagnosis and treatment with enthusiasm, and have published nearly 20 scientific research papers in global academic conferences and top journals, making outstanding contributions to promoting clinical research, health management and patient prognosis. This paper summary selected 6 splendid research results, hoping to help you better understand the clinical value of the functional diagnostic products independently developed by RainMed Medical.

 

04 caIMR System Can Assess Long-term Outcomes in Patients With STEMI

 

IMR is an ideal indicator for reflecting coronary microcirculation and predicting the prognosis of STEMI patients. However, measuring IMR with a pressure wire remains underutilized because of the complicated procedures The accuracy of caIMR has been validated multiple times compared to IMR. caIMR can be measured in an average of 5 minutes without a pressure wire or hyperemic agents, which offers a more convenient tool for detecting coronary microcirculation dysfunctions and providing scientific evidence for the diagnosis and treatment of microcirculation in clinical application.

 

On May 24, 2022, Professor Yuan Lu's team from The Affiliated Hospital of Xuzhou Medical University published a paper in JCR Q2 Frontiers in Physiology, evaluating the prognostic significance of caIMR on microvascular dysfunctions in STEMI patients. Results showed that the caIMR system is a promising prognostic method and caIMR>40, can predict cardiovascular death or heart failure readmission rates for STEMI patients at 1-year follow-up.

 

It is worth mentioning that this study evaluated the prognostic effects of drug-coated balloon (DCB) and drug-eluting stent (DES) interventions based on microvascular injury measured by the caIMR system. The results showed that the DCB strategy during primary percutaneous coronary intervention (PPCI) in STEMI patients may be a safe and feasible alternative strategy for DES treatment for less major adverse cardiovascular events (MACEs), providing new clinical evidence for the advanced diagnosis and treatment concept of "intervention without implantation" in clinical practice.

 

Read the paperhttps://www.frontiersin.org/articles/10.3389/fphys.2022.898659/full

 

05 The Post-PCI caIMR Can Accurately Predict Left Ventricular Functional Recovery

 

Although primary percutaneous coronary intervention (PCI) can restore the blood flow of the epicardial coronary artery, coronary microvascular dysfunction (CMD) still exists in patients with ST-segment elevation myocardial infarction (STEMI). IMR has been established as a gold standard for coronary microvascular assessment and a predictor of left ventricular recovery after STEMI. However, traditional wire-derived IMR is time-consuming, high-risk, and difficult to operate. Therefore, RainMed Medical has launched a safer and more convenient caIMR system.

 

On June 14, 2022, Professor Jian Liu's team from Peking University People's Hospital published a research paper in Journal of Interventional Cardiology. exploring the predictive value of postoperative caIMR measurement for left ventricular function recovery in STEMI patients undergoing PCI. Researchers used caIMR system to perform functional evaluations on STEMI patients 3 months after surgery. The results showed that the caIMR system can independently predict the postoperative left ventricular recovery of STEMI patients.

 

Previous studies have shown that the caIMR system has accurate diagnostic performance for coronary microvascular dysfunction and it has significant long-term prognostic value. This study further evaluated the predictive ability of caIMR system for left ventricular function recovery in 3 months in STEMI patients and demonstrated that the caIMR system can replace wire-derived IMR as a novel diagnostic and therapeutic approach, supporting large-scale clinical practice applications.

 

Read the paper: https://www.hindawi.com/journals/jitc/2022/9794919/ 

 

06 TIMI Frame Count Correlated Well With caIMR and Had Strong Predictive Power for Identifying CMD.

 

Patients with coronary slow flow (CSF) often experience various clinical adverse events, including acute myocardial infarction (AMI), malignant arrhythmia, and sudden cardiac death, with microcirculatory dysfunction being a potential cause. Although coronary microvascular dysfunction can explain the occurrence of slow blood flow, the relationship between the two is not clear.

 

On July 15, 2022, Professor Xiangqing Kong's team from Jiangsu Province Hospital published a paper in JCR Q2 Quantitative Imaging in Medicine and Surgery, studying the relationship between CSF and coronary microvascular dysfunction. The results showed that coronary microvascular dysfunction is commonly present in patients with CSF. Researchers used the caIMR system as a gold standard to evaluate coronary microvascular dysfunction and confirmed that corrected TIMI frame count can independently predict the coronary microvascular dysfunction. The best cutoff value of coronary TIMI frame count (CTFC) of all arteries for predicting CMD was 38 frames, with a sensitivity of 92.8% and a specificity of 63.8% (P<0.001).

 

In this study, the caIMR system was used as an evaluation index for coronary microvascular dysfunction to determine the optimal CTFC for evaluating coronary microvascular function. It can be seen that caIMR system, as a new intraoperative and convenient detection method for CMD evaluation, is being accepted and endorsed by a large number of doctors.

 

Read the paperhttps://qims.amegroups.com/article/view/98949/html

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